Oxycodone carries many Boxed Warnings for hazard of dependancy, overdose, and Demise; severe or fatal respiratory depression; fatalities from accidental ingestion by children; deadly Unwanted side effects when utilised with other respiratory depressants or CYP3A4 inhibitors; the chance of Neonatal Opioid Withdrawal syndrome in toddlers born depending on oxycodone; and the Opioid Analgesic REMS program.
Keep track of infants subjected to OXYCONTIN through breast milk for extra sedation and respiratory depression. Withdrawal indications can arise in breast-fed infants when maternal administration of an opioid analgesic is stopped, or when breast-feeding is stopped.
emphasize to clients as well as their caregivers the necessity of looking through the Medication Guidebook anytime it really is furnished by their pharmacist, and
Tolerance is often a physiological point out characterised by a diminished response into a drug right after repeated administration (i.e., an increased dose of a drug is needed to generate the same impact that was the moment acquired in a decreased dose).
Tell woman clients of reproductive probable that usage of OXYCONTIN for an prolonged time frame in the course of pregnancy may result in neonatal opioid withdrawal syndrome, which can be existence-threatening Otherwise regarded and addressed [see WARNINGS AND Safety measures and Use In Certain Populations].
Quick discontinuation has also been associated with attempts to seek out other sources of opioid analgesics, which can be confused with drug-in search of for abuse. People can also make an effort to address their soreness or withdrawal indications with illicit opioids, which include heroin, along with other substances.
Misuse may be the intentional use, for therapeutic functions, of a drug by somebody in a way besides prescribed by a well being care company or for whom it wasn't prescribed.
Patients at high chance of OXYCONTIN abuse include things like All those by using a heritage of extended use check here of any opioid, together with products and solutions made up of oxycodone, Those people that has a historical past of oxycontin drug or Alcoholic beverages abuse, or those who use OXYCONTIN in combination with other abused medicine.
Because these reactions are documented voluntarily from a populace of uncertain dimensions, it is not always feasible to reliably estimate their frequency or build a causal relationship to drug exposure.
Use is restricted by its potential for addiction and Unwanted side effects like respiratory depression and constipation. It really should not be utilised until finally a trial of oxycodone usual release has taken position and proved helpful.
For a guideline for Older people, the overall every day oxycodone dosage normally can be improved by twenty five% to 50% of the present whole day-to-day dosage, each time a boost is clinically indicated.
Alert people never to travel or work risky equipment Until They can be tolerant to the results of OXYCONTIN and understand how they're going to react towards the medication.
OXYCONTIN is click here formulated with inactive elements meant to make the pill harder to control for misuse and abuse. For that needs of describing the final results of research in the abuse-deterrent characteristics of OXYCONTIN ensuing from the adjust in formulation, Within this section, the initial formulation of OXYCONTIN, which happens to be now not promoted, are going to be known as “initial OxyContin” and also the reformulated, now promoted product will probably be generally known as “OXYCONTIN".
This drug passes into breast milk and might have undesirable results over a nursing toddler. Convey to the medical professional right away if your little one develops strange sleepiness, issue feeding, or trouble breathing. Talk to your health care provider in advance of breastfeeding.